Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres.

M I Filipe, F Potet, W V Bogomoletz, P A Dawson, B Fabiani, P Chauveinc, A Fenzy, B Gazzard, D Goldfain, R Zeegen

A joint prospective long term study of gastric biopsies has been undertaken to survey intestinal metaplasia Types I, II, and III in terms of their incidence, distribution and value in the selection of high risk cancer patients. This study is based on protocols agreed between three centres for endoscopy, histological interpretation, and mucin histochemistry. The results on the first 1350 gastric biopsies examined during 1981-1982 are presented. Intestinal metaplasia was found in 267 biopsies (20%), being common in association with carcinoma (71%), less so in benign conditions such as gastric ulcer (39%), and chronic gastritis (24%), but rare in 'normal' (3%). Type I intestinal metaplasia was predominant (73%) in all the biopsies with intestinal metaplasia and was most common in benign conditions, 70% in gastric ulcer and 76% in chronic gastritis. Type III intestinal metaplasia (incomplete sulphomucin-secreting intestinal metaplasia) was recorded in only 9.8% of all the biopsies with intestinal metaplasia and had a higher incidence in carcinoma (35%), than in benign conditions (7%) (p less than 0.0001). These results suggest that intestinal metaplasia types may have different malignant potential and their identification may be useful in screening patients for early detection of cancer.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Cunningham, S. C., Kamangar, F., Kim, M. P., Hammoud, S., Haque, R., Iacobuzio-Donahue, C. A., Maitra, A., Ashfaq, R., Hustinx, S., Heitmiller, R. E., Choti, M. A., Lillemoe, K. D., Cameron, J. L., Yeo, C. J., Schulick, R. D., Montgomery, E. (2006). Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions.. Cancer Epidemiol. Biomarkers Prev. 15: 281-287 [Abstract] [Full Text]  
• Niwa, T., Ikehara, Y., Nakanishi, H., Tanaka, H., Inada, K.-i., Tsukamoto, T., Ichinose, M., Tatematsu, M. (2005). Mixed Gastric- and Intestinal-type Metaplasia Is Formed by Cells with Dual Intestinal and Gastric Differentiation. J. Histochem. Cytochem. 53: 75-85 [Abstract] [Full Text]  
• Bodger, K, Campbell, F, Rhodes, J M (2003). Detection of sulfated glycoproteins in intestinal metaplasia: a comparison of traditional mucin staining with immunohistochemistry for the sulfo-Lewisa carbohydrate epitope. J. Clin. Pathol. 56: 703-708 [Abstract] [Full Text]  
• Oksanen, A, Sipponen, P, Karttunen, R, Rautelin, H (2003). Inflammation and intestinal metaplasia at the squamocolumnar junction in young patients with or without Helicobacter pylori infection. Gut 52: 194-198 [Abstract] [Full Text]  
• Andrianifahanana, M., Moniaux, N., Schmied, B. M., Ringel, J., Friess, H., Hollingsworth, M. A., Buchler, M. W., Aubert, J.-P., Batra, S. K. (2001). Mucin (MUC) Gene Expression in Human Pancreatic Adenocarcinoma and Chronic Pancreatitis: A Potential Role of MUC4 as a Tumor Marker of Diagnostic Significance. Clin. Cancer Res. 7: 4033-4040 [Abstract] [Full Text]  
• El-Zimaity, H M T, Ramchatesingh, J, Ali Saeed, M, Graham, D Y (2001). Gastric intestinal metaplasia: subtypes and natural history. J. Clin. Pathol. 54: 679-683 [Abstract] [Full Text]  
• Grotzinger, C, Kneifel, J, Patschan, D, Schnoy, N, Anagnostopoulos, I, Faiss, S, Tauber, R, Wiedenmann, B, Gessner, R (2001). LI-cadherin: a marker of gastric metaplasia and neoplasia. Gut 49: 73-81 [Abstract] [Full Text]  
• Bowrey, D J, Clark, G W B, Williams, G T (1999). Patterns of gastritis in patients with gastro-oesophageal reflux disease. Gut 45: 798-803 [Abstract] [Full Text]  
• Voutilainen, M, Farkkila, M, Juhola, M, Mecklin, J-P, Sipponen, P, The Central Finland Endoscopy Study Group, (1999). Complete and incomplete intestinal metaplasia at the oesophagogastric junction: prevalences and associations with endoscopic erosive oesophagitis and gastritis. Gut 45: 644-648 [Abstract] [Full Text]  
• Zullo, A, Romiti, A, Rinaldi, V, Vecchione, A, Tomao, S, Aiuti, F, Frati, L, Luzi, G (1999). Gastric pathology in patients with common variable immunodeficiency. Gut 45: 77-81 [Abstract] [Full Text]  
• Nomura, S, Kaminishi, M, Sugiyama, K, Oohara, T, Esumi, H (1998). Clonal analysis of isolated intestinal metaplastic glands of stomach using X linked polymorphism. Gut 42: 663-668 [Abstract] [Full Text]