Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.

T J Mitchell, J M Ketley, S C Haslam, J Stephen, D W Burdon, D C Candy, R Daniel

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

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