Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin.

A W Harris, P A Gummett, J J Misiewicz, J H Baron

Parkside Helicobacter Study Group, Central Middlesex Hospital, London.

BACKGROUND--Patients with duodenal ulcer (DU) have high basal (BAO) and peak (PAO) acid outputs. The effect of Helicobacter pylori eradication on these variables is unclear. AIM--To discover if gastric acid hypersecretion in patients with DU is caused by H pylori. PATIENTS AND METHODS--BAO, gastrin releasing peptide (GRP), and pentagastrin stimulated PAO in 10 H pylori negative controls, and in 10 H pylori positive patients with DU was measured before and six months after H pylori eradication. H pylori status was determined by histology, culture, and by the 13C-urea breath test. After collecting a 30 minute basal aspirate, GRP 40 pmol/kg/h was infused for 45 minutes, and after a 30 minute washout, pentagastrin 6 micrograms/kg was injected intramuscularly. RESULTS--Basal and stimulated acid output (PAOGRP and PAOPg) were significantly higher in H pylori positive DU than in H pylori negative controls. Six months after H pylori eradication, basal and stimulated acid outputs were all significantly lower than before H pylori eradication. CONCLUSIONS--This study has shown that BAO, PAOGRP, and PAOPg are higher in H pylori positive DU than in H pylori negative controls. All decreased significantly six months after H pylori eradication, to fall within the range of controls. These results are compatible with a hypothesis that acid hypersecretion in duodenal ulcer disease is caused by H pylori infection.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Articles

Gastric acid secretion.

I L Beales
Gut 1997 40: 155. [PDF]

Helicobacter pylori and duodenal ulcers.

O Oshowo and M Hobsley
Gut 1997 40: 155-156. [PDF]

This article has been cited by other articles:

• Behrman, S. W. (2005). Management of Complicated Peptic Ulcer Disease. Arch Surg 140: 201-208 [Full Text]  
• Barnett, K., Bell, C. J., McKnight, W., Dicay, M., Sharkey, K. A., Wallace, J. L. (2000). Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach. Am. J. Physiol. Gastrointest. Liver Physiol. 279: G1292-G1297 [Abstract] [Full Text]  
• Iijima, K, Ohara, S, Sekine, H, Koike, T, Kato, K, Asaki, S, Shimosegawa, T, Toyota, T (2000). Changes in gastric acid secretion assayed by endoscopic gastrin test before and after Helicobacter pylori eradication. Gut 46: 20-26 [Abstract] [Full Text]  
• Feldman, M., Cryer, B., Lee, E. (1998). Effects of Helicobacter pylori gastritis on gastric secretion in healthy human beings. Am. J. Physiol. Gastrointest. Liver Physiol. 274: G1011-G1017 [Abstract] [Full Text]