A prospective study of oesophageal function in patients with normal coronary angiograms and controls with angina
R A Cooke
a Department of Cardiology, b Department of Surgery, Guy's Hospital, London, UK
Correspondence to: Dr R A Cooke, Suite 303, Emblem House, London Bridge
Hospital, 27 Tooley Street, London SE1 2PR, UK. Accepted for publication 9 October 1997 Aims Keywords:
oesophageal function;
coronary artery disease;
chest pain
To compare the incidence of oesophageal
abnormalities and their correlation with chest pain in patients with
normal coronary angiograms, and in controls with angina.
PatientsSixty one patients with normal coronary
angiograms (NCA group) referred to a single cardiac centre between
March 1990 and April 1991; 25 matched controls with confirmed coronary artery disease (CAD group).
SettingCardiac referral centre and oesophageal
function testing laboratory.
Main outcome measuresOesophageal manometry,
provocation tests, and 24 hour ambulatory pH monitoring.
ResultsSimultaneous contractions were more
common (6.7% versus 0.8%, p<0.01), and the duration of peristaltic
contractions was longer (2.9 versus 2.4 seconds, p<0.01) in the NCA
group than in the CAD group. There were no group differences in the
amplitude of peristaltic contractions, and none had nutcracker
oesophagus. Ten (16%) patients with NCA and no patients with CAD had
diffuse spasm (p=0.03). Twenty one (34%) patients with NCA, and five
(20%) patients with CAD had abnormal gastro-oesophageal reflux
(p>0.05). There was no significant difference between the groups in
the number of patients whose pain was temporally related to pH events. Particular chest pain characteristics, or the presence of additional oesophageal symptoms, were not predictive of an oesophageal abnormality.
ConclusionOesophageal function tests
commonly implicate the oesophagus as a source of pain in patients with
normal coronary angiograms. With the exception of simultaneous
contractions during manometry however, the incidence of abnormalities
and in particular the correlation of pH events with chest pain are as
common in patients with normal coronary angiograms as in controls
with angina. The oesophagus may often be an unrecognised source of pain
in both groups of patients.
(GUT 1998;42:323-329)
© 1998 by Gut
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Oesophageal pain in coronary artery disease
- G GHILLEBERT and J JANSSENS
Gut 1998 42: 312-313.[Extract] [Full Text] [PDF]
This article has been cited by other articles:
-
Heatley, M, Rose, K, Weston, C
(2005). The heart and the oesophagus: intimate relations. Postgrad. Med. J.
81: 515-518
[Abstract] [Full Text] -
Wu, E.B., Cooke, R., Anggiansah, A., Owen, W., Chambers, J.B.
(2000). Are oesophageal disorders a common cause of chest pain despite normal coronary anatomy?. QJM
93: 543-550
[Full Text]
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
