Article
High prevalence of anti-hepatitis B virus serological markers in
patients with hepatitis C virus related chronic liver disease in
Japan
H Marusawaa, Y Osakib, T Kimurab, K Itoc, Y Yamashitad, T Eguchie, M Kudof, Y Yamamotog, H Kojimac, H Senoa, F Moriyasua, T Chibaa
a Division of
Gastroenterology and Hepatology, Department of Medicine, Postgraduate
School of Medicine, Kyoto University, Kyoto, Japan, b Department of Gastroenterology, Osaka Red Cross
Hospital, Osaka, Japan, c Department of Gastroenterology, Shizuoka General
Hospital, Shizuoka, Japan, d Department
of Gastroenterology, Kishiwada City Hospital, Osaka,
Japan, e Department of Gastroenterology, Kitano Hospital,
Osaka, Japan, f Department of Gastroenterology, Kobe City
General Hospital, Hyogo, Japan, g Department of Gastroenterology, Takatsuki
General Hospital, Osaka, Japan
Correspondence to: Dr T Chiba, Department of Gastroenterology and Hepatology, Department of Medicine, Postgraduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Accepted for publication 17 February 1999
BACKGROUND/AIMS
Evidence
is accumulating that hepatitis B virus (HBV) is present in patients who
are hepatitis B surface antigen negative but have antibody to hepatitis
B core antigen (anti-HBc). Furthermore, recent studies have shown that
patients with hepatocellular carcinoma who have antibody to hepatitis C
virus (HCV) often possess HBV related serological markers. Data on the
seroprevalence of HBV infection in patients with HCV related chronic
liver disease were collected to evaluate the significance of the
presence of antibodies to HBV.
METHODSThe prevalence
of HBV related serological markers was analysed in a total of 2014 Japanese patients with HCV infection. The control group comprised 352 subjects without liver disorder.
RESULTSA large number
of patients (49.9%) with HCV related chronic liver disease including
hepatocellular carcinoma were positive for anti-HBc. In addition, the
prevalence of anti-HBc closely correlated with the clinical stage of
the liver disease. There was no relation between a past history of
blood transfusion and the prevalence of anti-HBc. Notably, anti-HBc was
the only serological marker for HBV infection in a significant number
of patients with HCV related chronic liver disease (24.1%).
CONCLUSIONSOur data
provide further evidence for the high prevalence of anti-HBc in
patients with HCV related chronic liver disease, particularly those
with hepatocellular carcinoma, suggesting that HBV infection, probably
including latent infection, may play an important role in
carcinogenesis in these patients.
Keywords: hepatitis B virus; anti-HBc; hepatitis C virus; hepatocellular carcinoma
© 1999 by Gut
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