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Gut 2000;46:432-434 ( March )

Case report

Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus E Ichiishi, T Yoshikawa, T Kogawa, N Yoshida, M Kondo

First Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji Kamigyo-ku, Kyoto 602, Japan

Correspondence to: Dr E Ichiishi

Accepted for publication 22 September 1999

Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, the gastric cancer did not. However, the gastric tumour showed G-CSF receptor expression on immunohistochemical examination of sections. These findings suggest that the oesophageal cancer promoted gastric cancer growth by paracrine mechanisms involving G-CSF.


Keywords: cancer; gastric; oesophageal; stomach; granulocyte colony stimulating factor; receptor

© 2000 by Gut


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E. Obermueller, S. Vosseler, N. E. Fusenig, and M. M. Mueller
Cooperative Autocrine and Paracrine Functions of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in the Progression of Skin Carcinoma Cells
Cancer Res., November 1, 2004; 64(21): 7801 - 7812.
[Abstract] [Full Text] [PDF]


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