Article
High prevalence of potentially virulent strains of
Helicobacter pylori in the general male
British population
J Danesha, P Whincupb, M Walkerc, L Lennonc, A Thomsonc, P Applebyd, C Hawkeye, J C Athertone
a Clinical
Trial Service Unit and Epidemiological Studies Unit, University of
Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK, b Department of Public Health Sciences, St
George's Hospital Medical School, London SW17 0RE, UK, c Department of Primary Care and Population
Sciences, Royal Free UCL Medical School, London, UK, d ICRF Cancer
Epidemiology Unit, Oxford, UK, e Division
of Gastroenterology and Institute of Infections and Immunity,
University of Nottingham, UK
Correspondence to: Dr J Danesh
Accepted for publication 8 February 2000
BACKGROUND
Strains
of Helicobacter pylori that express the
cytotoxin associated gene product A (CagA) may be more strongly
associated with serious gastric diseases, such as gastric cancer and
peptic ulceration, than other strains. Data, however, are sparse on the prevalence, risk factors, and other correlates of these strains in
the general popu- lation.
AIMTo characterise
aspects of the seroepidemiology of CagA+ strains of
H pylori in the general British population.
METHODSWe measured
serum IgG antibodies to mixed H pylori
antigens and separately to CagA in 1025 men aged 40-59 years who were
randomly selected from a larger group of participants in a community
based survey conducted in 18 different British towns.
RESULTSOverall, 44%
(95% confidence interval 41-47%) of the men were seropositive to
CagA antibodies, representing about 61% (57-65%) of the men
seropositive to mixed antigen H pylori. The
risk factors for seropositivity to CagA antibodies were similar to
those for seropositivity to mixed antigen H
pylori, apart from an increased prevalence of reported bedroom
sharing in childhood (p<0.01).
CONCLUSIONIn a
nationwide study of potentially virulent H
pylori strains, there was a high prevalence of the infection,
with some evidence that acquisition of such strains might occur earlier
in life than other strains.
Keywords: Helicobacter pylori; cytotoxin associated gene A
© 2000 by Gut
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