Gut 2000;47:211-214 ( August )

Article

Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility J D Simmons^a, C Mullighan^b, K I Welsh^b, D P Jewell^a

^a Gastroenterology Unit, University of Oxford, Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6HE, UK, ^b Transplant Immunology, Transplant Centre, Churchill Hospital, Oxford, UK

Correspondence to: J D Simmons, Gastroenterology Unit, John Radcliffe Hospital, Oxford, OX3 9DU, UK. Email: jonsimmons{at}doctors.org.uk

Accepted for publication 8 February 2000

BACKGROUNDThe vitamin D receptor (VDR) gene represents a strong positional candidate susceptibility gene for inflammatory bowel disease (IBD). The VDR gene maps to a region on chromosome 12 that has been shown to be linked to IBD by genome screening techniques. It is the cellular receptor for 1,25(OH)₂ vitamin D₃ (calcitriol) which has a wide range of different regulatory effects on the immune system. IBD is characterised by activation of the mucosal immune system.
AIMTo determine if polymorphisms in the VDR gene are associated with susceptibility to IBD
SUBJECTSEuropean Caucasoids: 158 patients with ulcerative colitis, 245 with Crohn's disease, and 164 cadaveric renal allograft donor controls.
METHODSingle nucleotide polymorphisms (TaqI, ApaI, and FokI) in VDR were typed in patients with Crohn's disease, ulcerative colitis, and controls by polymerase chain reaction with sequence specific primers.
RESULTSThere were significantly more homozygotes for the TaqI polymorphism at codon 352 of exon 8 (genotype "tt") among patients with Crohn's disease (frequency 0.22) than patients with ulcerative colitis (0.12) or controls (0.12) (odds ratio 1.99; 95% confidence interval 1.14-3.47; p=0.017).
CONCLUSIONThis study provides preliminary evidence for a genetic association between Crohn's disease susceptibility and a gene that lies within one of the candidate regions determined by linkage analysis.


Keywords: inflammatory bowel disease; genetics; candidate genes; vitamin D

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© 2000 by Gut
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