DYSPEPSIA MANAGEMENT

Combined analysis of the ORCHID and OCAY studies: does eradication of Helicobacter pylori lead to sustained improvement in functional dyspepsia symptoms?

S J O Veldhuyzen van Zanten¹, N J Talley², A L Blum³, E Bolling-Sternevald⁴, M Sundin⁵, O Junghard⁵

¹ Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada
² Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
³ Division of Gastroenterology, Department of Medicine, University Hospital, Lausanne, Switzerland
⁴ Department of Biomedicine and Surgery, University Hospital, Linköping, Sweden
⁵ AstraZeneca R&D, Mölndal, Sweden

Correspondence to:
Correspondence to:
Dr S J O Veldhuyzen van Zanten, Division of Gastroenterology, Dalhousie University, Queen Elizabeth II Health Science Centre, Victoria General Site, Room 928, Centennial Building, Halifax, Nova Scotia, Canada B3H 2YG;
zanten{at}is.dal.ca

Currently, one of the most important unresolved questions concerning Helicobacter pylori is whether eradication of the organism leads to a sustained improvement in symptoms in patients diagnosed with functional (non-ulcer) dyspepsia. Recently, two very similar studies, the ORCHID and OCAY studies, have been completed and the combined results of these two multicentre, multinational, randomised, double blind, controlled clinical trials are reviewed.

Keywords: clinical trial; dyspepsia; Helicobacter pylori; OCAY study; ORCHID study; quality of life; symptom relief

Abbreviations: GDSS, Glasgow dyspepsia severity score; GORD, gastro-oesophageal reflux disease; GSRS, gastrointestinal symptom rating scale; ITT, intention to treat; MRC, Medical Research Council; OAC, omeprazole 20 mg twice daily, amoxycillin 1000 mg twice daily, and clarithromycin 500 mg twice daily for seven days; PGWB, psychological general well being

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