DYSPEPSIA MANAGEMENT

The potential role of acid suppression in functional dyspepsia: the BOND, OPERA, PILOT, and ENCORE studies

N J Talley¹ and K Lauritsen²

¹ Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
² Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark

Correspondence to:
Correspondence to:
Professor N J Talley, Department of Medicine, University of Sydney, Nepean Hospital, Penrith 2751, NSW, Australia;
ntalley{at}blackburn.med.su.oz.au

Dyspepsia is a common condition in the general population but data are lacking on the benefits of effective acid inhibition with proton pump inhibitors in functional dyspepsia. The results of the large, randomised, double blind clinical trials, BOND and OPERA, the Scandinavian PILOT study, and a follow up study, ENCORE, are reviewed. BOND, OPERA, and PILOT aimed to address the question of whether effective acid inhibition with the proton pump inhibitor omeprazole relieves symptoms in patients with functional dyspepsia. ENCORE followed on from this, addressing the consequences of relieving symptoms in patients with functional dyspepsia once they are off therapy.

Keywords: dysmotility; functional dyspepsia; Helicobacter pylori; omeprazole; reflux; ulcer

Abbreviations: GORD, gastro-oesophageal reflux disease; GSRS, gastrointestinal symptom rating scale; ITT, intention to treat; MBS, most bothersome symptom; PGWB, psychological general well being

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Articles

Natural history of dyspepsia

L Agréus
Gut 2002 50: iv2-iv9. [Abstract] [Full Text] [PDF]

Assessment of outcome in dyspepsia: has progress been made?

S J O Veldhuyzen van Zanten
Gut 2002 50: iv23-iv25. [Abstract] [Full Text] [PDF]