VISCERAL PERCEPTION

Visceral perception: sensory transduction in visceral afferents and nutrients

H E Raybould

Correspondence to:
Correspondence to:
Dr H Raybould, Vet Med: APC, 1321 Haring Hall, UC Davis School of Veterinary Medicine, Davis, CA 95616, USA;
heraybould{at}ucdavis.edu

The possible mechanisms that may be involved in nutrient detection in the wall of the gastrointestinal tract are reviewed. There is strong functional and electrophysiological evidence that both intrinsic and extrinsic primary afferent neurones mediate mechano- and chemosensitive responses in the gastrointestinal tract. This review focuses on the extrinsic afferent pathways as these are the ones that convey information to the central nervous system which is clearly necessary for perception to occur.

Keywords: serotonin; afferent nervous system; cholecystokinin; enteroendocrine cells; enterochromaffin cells; apolipoprotein A-IV; cellular glucose transport

Abbreviations: apo, apolipoprotein; CCK, cholecystokinin; CNS, central nervous system; EC, enteroendocrine cells; GLUT, glucose transporter; SGLT, sodium-glucose cotransporter; 5-HT, serotonin

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