VISCERAL PERCEPTION

Gastric hyperalgesia and changes in voltage gated sodium channel function in the rat

G F Gebhart¹, K Bielefeldt², N Ozaki¹

¹ Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA
² Department of Internal Medicine (Gastroenterology), College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA

Correspondence to:
Correspondence to:
Dr G F Gebhart, Department of Pharmacology, University of Iowa, College of Medicine, 2-471 Bowen Science Building, Iowa City, IA 52242-1109, USA;
gf-gebhart{at}uiowa.edu

Potential peripheral mechanisms that might contribute to the development of visceral hypersensitivity and ultimately to the altered sensations that characterise functional gastrointestinal disorders were examined by developing experimental models of gastric hyperalgesia. A direct link between alteration in behaviour and potential mechanisms of increased excitability of the gastric afferent innervation was found.

Keywords: sensitisation; excitability; hyperalgesia; sodium current; tetrodotoxin

Abbreviations: CNS, central nervous system; HAc, acetic acid; IBS, irritable bowel syndrome; NGF, nerve growth factor; TTX, tetrodotoxin

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