VISCERAL PERCEPTION

Prevertebral ganglia and intestinofugal afferent neurones

J H Szurszewski, L G Ermilov, S M Miller

Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, 55905 USA

Correspondence to:
Correspondence to:
Dr J H Szurszewski, Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA;
gijoe{at}mayo.edu

Intestinofugal afferent neurones (IFANs) are a unique subset of myenteric ganglion neurones that regulate normal gastrointestinal function. The IFANs relaying mechanosensory information to sympathetic neurones of the prevertebral ganglion (PVG) function as volume detectors. It is possible that mechanosensory information arriving in the PVG via axon collaterals of visceral spinal afferent nerves can be modulated entirely within the PVG itself.

Keywords: prevertebral ganglia; sympathetic neurones; intestinal afferent nerves; mechanosensitivity

Abbreviations: CGRP, calcitonin gene related peptide; F-EPSP, fast excitatory postsynaptic potential; GABA, gamma aminobutyric acid; IFAN, intestinofugal afferent neurone; IMA, intramuscular array; IMG, inferior mesenteric ganglion; IPAN, intrinsic primary afferent neurone; PVG, prevertebral ganglion; S-EPSP, slow excitatory postsynaptic potential; SMG, superior mesenteric ganglion; SP, substance P; VIP, vasoactive intestinal peptide

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