© 2002 by Gut
VISCERAL PERCEPTION
Pathophysiology of functional dyspepsia
Correspondence to:
Correspondence to:
Dr M Thumshirn, Department of Gastroenterology, University Hospital Zurich, Raemistrasse 100, CH- 8091 Zürich, Switzerland;
miriam.thumshirn{at}DIM.usz.ch
Functional dyspepsia is a symptom complex characterised by postprandial upper abdominal discomfort or pain, early satiety, nausea, vomiting, abdominal distension, bloating, and anorexia in the absence of organic disease. Gastrointestinal motor abnormalities, altered visceral sensation, and psychosocial factors have all been identified as major pathophysiological mechanisms. This perspective has now replaced the earlier view that the condition was the result of a sole motor or sensory disorder of the stomach. Future therapeutic strategies should be aimed at reducing nociception as well as enhancing the accommodation response.
Keywords: functional dyspepsia; Helicobacter pylori; gastric accommodation; hypomotility
Abbreviations: IBS, irritable bowel syndrome
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