COMMENTARY

Small intestine

HLA-DQ8 as an Ir gene in coeliac disease

K E A Lundin

Department of Medicine and Institute of Immunology, Rikshospitalet, N-0027 Oslo, Norway; knut.lundin{at}rikshospitalet.no

DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease

Keywords: coeliac disease; gliadin peptides; HLA restriction; organ culture; mucosal immunity; Ir genes coeliac

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