REVIEW

Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?

G-T Ho, F M Moodie, J Satsangi

University Department of Medical Sciences, Western General Hospital, Edinburgh, UK

Correspondence to:
Correspondence to:
Dr G-T Ho, Gastrointestinal Laboratories, Western General Hospital, Edinburgh EH4 2XU, UK;
gho{at}ed.ac.uk

The interface between luminal contents and intestinal epithelium constitutes the largest area of interaction between the host and the environment. There is now strong evidence that the gene product of the multidrug resistant pump (MDR) plays a critical role in host-bacterial interactions in the gastrointestinal tract and maintenance of intestinal homeostasis. This review highlights the efflux mechanism in the intestinal epithelium which is mediated by the multidrug resistant pump, also known as P-glycoprotein 170. Current studies promise to provide further insights into the contribution of the MDR1 gene in the pathogenesis of inflammatory and malignant disorders of the gastrointestinal tract.

Keywords: multidrug resistance 1 gene; P-glycoprotein 170; drug resistance; inflammatory bowel disease; colorectal cancer

Abbreviations: MDR, multidrug resistance; IBD, inflammatory bowel disease; NFB, nuclear factor B; IB, inhibitory protein B; SNP, single nucleotide protein; PBL, peripheral blood lymphocytes; CYP3A, cytochrome P450 3A

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