LEADING ARTICLE

Liver tolerance mediated by antigen presenting cells: fact or fiction?

A H Lau¹, A de Creus², L Lu², A W Thomson¹

¹ Department of Surgery and Department of Immunology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
² Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA

Correspondence to:
Correspondence to:
Dr A Thomson, Departments of Surgery and Immunology, University of Pittsburgh Medical Center, W1544 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15213, USA;
thomsonaw{at}msx.upmc.edu

Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver.

Keywords: liver tolerance; antigen presenting cells

Abbreviations: Ag, antigen; MHC, major histocompatibility complex; APC, antigen presenting cells; DC, dendritic cells; LSEC, liver sinusoidal endothelial cells; KC, Kupffer cells; IL, interleukin; TGF, transforming growth factor; PG, prostaglandin; NK, natural killer; TNF, tumour necrosis factor; Th, T helper; Treg, regulatory T cells; IFN, interferon; CTLA4Ig, cytotoxic T lymphocyte Ag 4 immunoglobulin

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Yadav, N., Kanjirakkuzhiyil, S., Kumar, S., Jain, M., Halder, A., Saxena, R., Mukhopadhyay, A. (2009). The therapeutic effect of bone marrow-derived liver cells in the phenotypic correction of murine hemophilia A. Blood 114: 4552-4561 [Abstract] [Full Text]