LEADING ARTICLE

Dysbiosis in inflammatory bowel disease

C P Tamboli¹, C Neut², P Desreumaux³, J F Colombel³

¹ Division of Gastroenterology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
² Laboratoire de Bacteriologie, Faculté de Pharmacie, Lille and INSERM EPI0114, CHU Lille, France
³ Service d’Hepatogastroenterologie, Hopital Huriez and INSERM EPI0114, CHU Lille, France

Correspondence to:
Correspondence to:
Dr C P Tamboli
Division of Gastroenterology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 4544 JCP, 200 Hawkins Drive, Iowa City, Iowa, USA; cyrus-tamboli{at}uiowa.edu

Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive. One theory has suggested a breakdown in the balance between putative species of "protective" versus "harmful" intestinal bacteria—this concept has been termed "dysbiosis". Arguments in support of this concept are discussed.

Keywords: inflammatory bowel disease; dysbiosis; intestinal bacteria

Abbreviations: IBD, inflammatory bowel disease; CD, Crohn’s disease; IL, interleukin; PCR, polymerase chain reaction; UC, ulcerative colitis

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