LEADING ARTICLE

Food allergy in irritable bowel syndrome: new facts and old fallacies

E Isolauri¹, S Rautava¹, M Kalliomäki²

¹ Department of Paediatrics, University of Turku and Turku University Central Hospital, Finland
² Massachusetts General Hospital East, Combined Program in Pediatric Gastroenterology and Nutrition, Charlestown, Massachusetts, USA

Correspondence to:
Correspondence to:
Dr E Isolauri
Department of Paediatrics, Turku University Central Hospital, 20520 Turku, Finland; erika.isolauri{at}utu.fi

The notion of food allergy in irritable bowel syndrome (IBS) is not new. However, recent evidence suggests significant reduction in IBS symptom severity in patients on elimination diets, provided that dietary elimination is based on foods against which the individual had raised IgG antibodies. These findings should encourage studies dissecting the mechanisms responsible for IgG production against dietary antigens and their putative role in IBS

Abbreviations: IBS, irritable bowel syndrome; PRR, pattern recognition receptor

Keywords: food allergy; irritable bowel syndrome

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