© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
LEADING ARTICLE
Endothelin and vascular function in liver disease
Correspondence to:
Correspondence to:
Professor K Moore
Centre for Hepatology, Royal Free and University College Medical School, University College London, Rowland Hill St, London NW3 2PF, UK; kmoore{at}rfc.ucl.ac.uk
The endothelins are a group of three related peptides with two receptor subtypes, ETA and ETB. Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogenesis of acute renal failure, including hepatorenal syndrome, has also been speculated.
Keywords: endothelin; vascular function; liver disease
Abbreviations: ET-1, endothelin 1; HRS, hepatorenal syndrome; RBF, renal blood flow; FBF, forearm blood flow
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