LEADING ARTICLE

Clinical implications of E-cadherin associated hereditary diffuse gastric cancer

R C Fitzgerald, C Caldas

Hutchison/MRC Research Centre, Cambridge, UK

Correspondence to:
Correspondence to:
Dr R Fitzgerald
Hutchison/MRC Research Centre, Hills Rd, Cambridge CB2 2XZ, UK; rcf{at}hutchison-mrc.cam.ac.uk

Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).

Keywords: E-cadherin; gastric cancer; gastrectomy; genetic susceptibility; screening

Abbreviations: HDGC, hereditary diffuse gastric cancer

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