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Interface between the intestinal environment and the nervous system

O Lundgren

Correspondence to:
Correspondence to:
Professor O Lundgren
Department of Physiology, Sahlgrenska Academy, Göteborg University, Box 432, S-405 30 Göteborg, Sweden; ove.lundgren{at}fysiologi.gu.se

Possible mechanisms by which the intestinal contents may influence afferent nerve fibres in the lamina propria of the intestinal mucosa are discussed in this brief review. After addressing intestinal epithelial permeability, endocrine and brush cells are discussed, as well as enterocytes, as sensors for luminal microbes.

Keywords: intestinal environment; nervous system; visceral afferent mechanism

Abbreviations: CCK, cholecystokinin; EC, enterochromaffin; cAMP, cyclic adenosine monophosphate; 5-HT, 5-hydroxytryptamine; CNS, central nervous system; NO, nitric oxide; NOS1, nitric oxide synthase 1

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M Costa, H Glise, and H Graffner
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