INFLAMMATORY BOWEL DISEASE

Dynamics of mucosal permeability and inflammation in collagenous colitis before, during, and after loop ileostomy

A Münch¹, J D Söderholm², C Wallon², Å Öst³, G Olaison², M Ström¹

¹ Department of Gastroenterology, UHL, Linköping, Sweden
² Department of Surgery, UHL, Linköping, Sweden
³ Medilab, Täby, Sweden

Correspondence to:
Correspondence to:
Dr M Ström
Department of Gastroenterology, Linköping University Hospital, SE-58185 Linköping, Sweden; Magnus.Strom{at}lio.se

Collagenous colitis has become a more frequent diagnosis but the aetiology of this disease is still unknown. We describe a female patient with intractable collagenous colitis who was treated with a temporary loop ileostomy. She was followed clinically, histopathologically, and functionally by measuring mucosal permeability before surgery, after ileostomy, and after bowel reconstruction. In our case report, active collagenous colitis was combined with increased transcellular and paracellular mucosal permeability. Diversion of the faecal stream decreased inflammation of the mucosa and normalised epithelial degeneration and mucosal permeability. After restoration of bowel continuity, mucosal permeability was altered prior to the appearance of a collagenous layer.

Abbreviations: CC, collagenous colitis; Cr-EDTA, chromium-ethylenediaminetetraacetate; HRP, horseradish peroxidase; IBD, inflammatory bowel disease; Isc, short circuit current; Pd, transepithelial potential difference; TER, transepithelial resistance; IEL, intraepithelial lymphocytes

Keywords: collagenous colitis; mucosal permeability; Ussing chamber

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Digest

Robin Spiller
Gut 2005 54: 1051. [Extract] [Full Text] [PDF]