CASE REPORT

p53 gene (Gendicine) and embolisation overcame recurrent hepatocellular carcinoma

Y S Guan, Y Liu, X P Zhou, X Li, Q He, L Sun

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuang Province, China

Correspondence to:
Professor Y-S Guan
Department of Radiology, West China Hospital, Sichuan University, 37 Guoxuexiang, Chengdu 610041, Sichuan Province, China; YongsongGuan{at}yahoo.com

Transcatheter arterial chemoembolisation (TACE) has become the standard treatment for unresectable hepatocellular carcinoma (HCC). However, this method is often unsuccessful. The p53 gene, which is present as a mutant form in many human tumours, is known to have broad spectrum antitumour effects when expressed normally. In this study, we report a 23 year old patient with recurrent HCC who was treated with the p53 gene (Gendicine) combining TACE, which resulted in a good clinical prognosis.

Abbreviations: TACE, transcatheter arterial chemoembolisation; HCC, hepatocellular carcinoma; CT, computed tomography; VP, virus particles

Keywords: hepatocellular carcinoma; p53 gene; transcatheter arterial chemoembolisation

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