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Central sensitisation in visceral pain disorders
1 Department of Medicine, University of Florida Colleges of Medicine and Dentistry, Gainesville, Florida, USA
2 Department of Oral and Maxillofacial Surgery, and Department of Neuroscience, University of Florida Colleges of Medicine and Dentistry, Gainesville, Florida, USA
3 Department of Medicine, University of Florida Colleges of Medicine and Dentistry, Gainesville, Florida, USA, and North Florida/South Georgia VA Medical System, Florida, USA
Correspondence to:
Correspondence to:
Dr G N Verne
University of Florida College of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, 1600 SW Archer Rd, HD 602, PO Box 100214, Gainesville, FL 32610-0214, USA; GNicholas.Verne{at}medicine.ufl.edu
The concepts of visceral hyperalgesia and visceral hypersensitivity have been examined in a variety of functional gastrointestinal disorders (FGIDs). Although the pathophysiological mechanisms of pain and hypersensitivity in these disorders are still not well understood, exciting new developments in research have been made in the study of the brain-gut interactions involved in the FGIDs
Abbreviations: FGIDs, functional gastrointestinal disorders; IBS, irritable bowel syndrome; FM, fibromyalgia
Keywords: visceral hypersensitivity; secondary hyperalgesia; central sensitisation; irritable bowel syndrome; hyperalgesia; temporal summation
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Gut 2006 55: 926-932.
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