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The IL23 axis plays a key role in the pathogenesis of IBD

Dermot McGovern¹, Fiona Powrie²

¹ Imperial College, London, Hammersmith Hospital Campus, Du Cane Road, London, UK
² Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford, UK

Correspondence to:
Correspondence to:
Dermot McGovern
Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK; dermotmcgovern{at}doctors.net.uk

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

Abbreviations: DC, dendritic cell; IBD, irritable bowel disease; IFN, interferon ; IL, interleukin; IL23R, interleukin 23 receptor; SNP, single-nucleotide polymorphism; TGFß, transforming growth factor ß; Th, T helper; TNF, tumour necrosis factor

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