Recent advances in basic science
Novel ways to sensitise gastrointestinal cancer to apoptosis
First Medical Department, University of Mainz, Mainz, Germany
Correspondence to:
Dr H Schulze-Bergkamen, First Medical Department, University of Mainz, Langenbeckstrasse 1, D-55101 Mainz, Germany; bergkam{at}uni-mainz.de
Gastrointestinal (GI) cancers are major health problems, being the most common cancers worldwide. Resistance to apoptosis is closely linked to carcinogenesis and enables malignant cells to evade therapy-induced cell death. In the recent past, the increasing understanding of molecular pathways of apoptosis has provided novel targets in cancer therapy. Several drugs, either inhibiting antiapoptotic signalling or actively inducing apoptosis in cancer cells, have already entered clinical trials. Until now, agents targeting apoptosis pathways are primarily being tested alone or in combination with chemotherapy. In the near future, personalised combination therapies will probaby be beneficial for patients with GI cancer. In this review, the current knowledge on defects in apoptosis signalling in GI cancer is summarised and the focus is on the potential clinical efficacy of apoptosis targeting agents.
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