LEADING ARTICLE
The aging stomach: implications for NSAID gastropathy
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Over 30 million people worldwide use non-steroidal
anti-inflammatory drugs (NSAIDs) daily, and nearly 50% of these NSAID
users are elderly.1 2
Numerous human studies have shown
that the use of NSAIDs is associated with various gastroduodenal
mucosal lesions,2-4 sometimes collectively referred to as
NSAID gastropathy,4 and that NSAID gastropathy and its
life-threatening complications occur primarily in elderly
patients.5 6
Overall, the use of NSAIDs increases the
risk of peptic ulcer disease, ulcer complications (haemorrhage and/or
perforation), and death from ulcer by a factor of between 2 and
4.3 5 7
In the United States alone, medical costs
attributable to NSAID gastropathy and its complications exceed $4
(£2.4) billion a year.2 Although increased NSAID use
among the elderly is an obvious risk factor, epidemiological data
suggest that aging is an independent risk factor for the development of
NSAID gastropathy and its complications.5 6 8
The aim of
this article is to review recent developments in the area of age
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Gut 1997 41: 421.[Extract] [Full Text] [PDF]
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