COMMENTARY
See article on page 120
Coeliac disease and primary biliary cirrhosis: a case for mutual screening
| The first 150 words of the full text of this article appear below. |
The paper by Kingham and Parker (see page 120) provides a strong take home message regarding the importance of establishing associations between diseases which, although relatively rare, have an impact on the health of a relatively young population. The authors have demonstrated an association between the two disorders and suggest that patients with one disease should be tested for the other. Is this advice justified?
Justification for such targeted screening depends on three things: the robustness of the association; the simplicity and reliability of the diagnostic tests; and the evidence that early detection benefits the patient.
The study aims to make a rigorous assessment of the previously
described association between coeliac disease and primary biliary cirrhosis,1 and establish relative prevalences of the
two diseases. Gastroenterologists in South Wales have kept a register
of specifically defined gastrointestinal diseases since 1984, using ICD
coding from all in- and outpatient and day case attendances
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- The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences
- J G C Kingham and D R Parker
Gut 1998 42: 120-122.[Abstract] [Full Text] [PDF]
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