GUT 1998;42:157-158 ( February )

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Interleukin 10 is a growth factor for a population of regulatory T cells

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A hallmark of the intestinal immune system is its ability to mount a rapid and potent effector response to pathogenic bacteria, viruses and parasites, while remaining tolerant to the vast array of luminal bacteria and ingested antigens. It is generally considered that the breakdown of this tolerance is of crucial importance in the development of inflammatory bowel disease (IBD) in humans. The mechanisms governing immune responsiveness and non-responsiveness in the intestine are not well understood; however, the recent finding that IBD develops in mice which lack particular T cell subsets (severe combined immunodeficient (SCID) mice restored with CD45RB^high CD4+ T cells^{1 2} and T cell receptor- chain deficient mice³ ), or in mice with targeted deletions of the interleukin (IL)-10 (IL-10KO)⁴ or IL-2 (IL-2KO)⁵ genes suggests that T cell subsets and cytokines play an active role in regulating potentially tissue damaging immune responses in the intestine. Although these models may . . . [Full text of this article]

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