COMMENTARY
See article on page 344
Capsaicin sensitivity and epidermal growth factor
| The first 150 words of the full text of this article appear below. |
It is now well established that afferent neurones innervating
the intestine subserve "effector" as well as sensory functions. The
release of neuromodulators from the peripheral nerve terminals of
extrinsic afferents has been shown to play a role in the regulation of
blood flow and secretory and motor functions of the gastrointestinal tract.1 In animals (but not in humans) most of the
extrinsic spinal sensory neurones express calcitonin gene related
peptide (CGRP) or substance P, or both.2 The role of
afferent neurones and these neuropeptides in the regulation of gastric
mucosal integrity has received much attention. Experimental injury in
the rat stomach induced by pyloric ligation or injurious factors, such
as hydrochloric acid, taurocholate, aspirin, and ethanol, is reduced by
stimulation of extrinsic afferent nerve terminals by intragastric
administration of capsaicin prior to the injurious agent. In addition,
intragastric administration of capsaicin increases gastric mucosal
blood flow (GMBF). This protective effect
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- Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow
- J Y Kang, C H Teng, F C Chen, and A Wee
Gut 1998 42: 344-350.[Abstract] [Full Text] [PDF]
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