SCIENCE ALERT
The alpha-smooth muscle actin promoter: a useful tool to analyse autocrine and paracrine roles of mesenchymal cells in normal and diseased bowel
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Comment
IGF-I AND NORMAL OR ADAPTIVE GROWTH OF BOWEL
IGF-I mediates many of the postnatal growth promoting actions of
pituitary derived growth hormone (GH) on multiple organs between birth
and puberty and during adulthood.1 2
The bowel is now
well established as an important target organ for GH and
IGF-I.1 2
GH and IGF-I are currently being used in
clinical trials to improve bowel function in patients with short bowel
syndrome.3 4
IGF-I seems to mediate many of the enterotrophic actions of GH, which in turn increases circulating concentrations and local expression of IGF-I in bowel.2 5
Previous studies in transgenic mice overexpressing metallothionen promoter I driven human IGF-I transgenes (MT-hIGF-I mice) or bovine GH
transgenes (MT-bGH mice) revealed major increases in the mass of
intestinal mucosa and in small bowel length relative to wild type.5 6
MT-hIGF-I mice have elevated circulating IGF-I, local overexpression of IGF-I in intestine and GH
deficiency.6 Despite the deficiency
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Pucilowska, J. B., McNaughton, K. K., Mohapatra, N. K., Hoyt, E. C., Zimmermann, E. M., Sartor, R. B., Lund, P. K.
(2000). IGF-I and procollagen alpha 1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease. Am. J. Physiol. Gastrointest. Liver Physiol.
279: G1307-G1322
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