LEADING ARTICLE
From genes to genome biology: a new era in Helicobacter pylori research
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Introduction |
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In August 1997 the complete annotated genome sequence of Helicobacter pylori was published,1 just 15 years after the organism was first cultured.2 This is an important milestone in gastroenterology research as H pylori is the first enteropathogen to be fully sequenced. The availability of a complete genetic data set heralds a new era in H pylori research as it will provide a framework for global studies of virulence and other aspects of the organism's biology. In this article we outline the genomics approaches that can now be applied and highlight the potential practical benefits of this research in terms of eradication therapy and disease prevention.
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The H pylori genome sequence: new opportunities |
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Scientists at The Institute for Genomic Research (TIGR)
(http://www.tigr.org) have determined the order of the 1 667 867
nucleotides that constitute the circular chromosomal content of H
pylori strain ACTC 26695.1 Initial computer
analysis suggests the presence of 1590 open reading frames (ORFs or
genes), of which nearly
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