COMMENTARY
See article on page 538
Gut epithelium: food processor for the mucosal immune system?
| The first 150 words of the full text of this article appear below. |
To those outside the field of mucosal immunology it must seem
incredible that we do not yet understand something so basic as the
interaction of protein antigens with the intestinal epithelium. Although we now know in some detail the mechanisms by which the mucosal
immune system is regulated and we can construct elegant adjuvant-peptide fusion proteins with systems capable of precise delivery in conjunction with what we think are appropriate cytokines, we know very little of what happens to even the most simple protein antigens during transport. Conversely, the emergence of several good
rodent models of intestinal inflammation has had a major impact on our
understanding of inflammatory bowel disease pathogenesis, but without
further information on T cell-epithelial cell-antigen interactions,
the vital mechanisms of the initial "barrier" defect will continue
to elude us. Are antigens selectively degraded during transport across
the epithelium? If so, is this essential to the maintenance
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