SCIENCE ALERT
Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease
| Table Removed (Available Only in the Full Text) |
| The first 150 words of the full text of this article appear below. |
Comment
Rats given an intracolonic injection of the contact sensitising
agent trinitrobenzene sulphonic (TNBS) acid dissolved in ethanol develop transmural inflammation resembling Crohn's disease. Although the model has limitations, the advantage of the system is that it
allows pre-clinical studies on possible treatments to be easily carried
out, and it is a much easier system to work with than the spontaneous
models of inflammatory bowel disease (IBD) which occur in gene knockout
mice. Tissue injury in this model is T cell mediated, and the response
is against both the hapten and the normal flora. The T cell response is
highly skewed towards Th1 and there is abundant interferon (IFN) 
and tumour necrosis factor (TNF) 
in the mucosa, again like Crohn's
disease. As it is now well established that Th1 responses can be
dramatically down-regulated by Th2 cytokines such as interleukin (IL) 4 and IL-10, Hogaboam et al have attempted to find
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Barbara, G, Xing, Z, Hogaboam, C M, Gauldie, J, Collins, S M
(2000). Interleukin 10 gene transfer prevents experimental colitis in rats. Gut
46: 344-349
[Abstract] [Full Text] -
Wirtz, S, Galle, P R, Neurath, M F
(1999). Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure. Gut
44: 800-807
[Abstract] [Full Text]
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
