COMMENTARY
See article on page 48
Life (and death) in the Fas lane
| The first 150 words of the full text of this article appear below. |
The hallmark of an immune response is the generation of a large
new cohort of specific lymphocytes dedicated to the removal of the
stimulating antigen. The protection afforded by the mobilisation of an
army of potentially destructive cells comes at a price as these cells,
if uncontrolled, may turn on the host. Thus when excessive immune
activity occurs, immunopathology resulting from the "friendly fire"
of inflammatory cells may compromise healthy tissue. To safeguard
against this, mechanisms have evolved that remove the expanded
population of leucocytes both at the end of the immune response, when
antigen is eradicated, and also when excessive activation may be taking
place.1 The ligation of a surface membrane molecule CD95
(Fas/Apo-1) on activated T cells by its ligand leads to
apoptosis.2 Although once activated, the expression of the
CD95 receptor is stable, the expression of CD95 (Fas)-ligand, which is
also found on T cells, is transient
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Gut 1998 43: 48-55.[Abstract] [Full Text] [PDF]
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