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Eradication of chronic Helicobacter pylori infection by therapeutic vaccination
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Comment
Effective antibiotic based therapies for eradicating
Helicobacter pylori have been developed in
recent years.1 2
There is, however, an the increasing
problem of antibiotic resistance in H
pylori3 and in the long term the consequence of
large scale eradication programmes could be a reduction in the efficacy of current antibiotic based regimens.
The development of a vaccine against H
pylori which confers long term protective immunity is the best
strategy to circumvent the problem of antibiotic resistance and to
eradicate H pylori on a global scale. The
feasibility of inducing protective immune responses to helicobacter by
oral vaccination with bacterial antigens and a mucosal adjuvant was
initially demonstrated in the H felis murine
model.4-6 Vaccination with both H
pylori urease5 and heat shock proteins (HspA and
HspB)6 protected against subsequent challenge with
H felis. However, H
felis lacks many of the virulence factors present in
H pylori, such
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This article has been cited by other articles:
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Kusters, J. G., van Vliet, A. H. M., Kuipers, E. J.
(2006). Pathogenesis of Helicobacter pylori Infection. Clin. Microbiol. Rev.
19: 449-490
[Abstract] [Full Text] -
Harris, A. G., Hazell, S. L., Netting, A. G.
(2000). Use of digoxigenin-labelled ampicillin in the identification of penicillin-binding proteins in Helicobacter pylori. J Antimicrob Chemother
45: 591-598
[Abstract] [Full Text]
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