COMMENTARY
See article on page 494
Appendicectomy and childhood hygiene: different sides of the same coin?
| The first 150 words of the full text of this article appear below. |
The aetiology of ulcerative colitis and Crohn's disease
remains an enigma. There is, however, a growing consensus that early events/exposure are of importance and constitute a "window of opportunity". Both analytical and observational studies as well as
animal models give credence to this hypothesis. Smoking has, until
recently, been the only factor that has been consistently associated
with an increased risk of Crohn's disease and a decreased risk of
ulcerative colitis. Appendicectomy has now been added to this very
short list as there has been a consistent finding in several studies
that this operation is associated with a decreased risk of ulcerative
colitis.1 2
Duggan et al's study (see page
494) confirms these results. Their findings for childhood hygiene are
in accordance with previous studies where the availability of hot
running water is associated with Crohn's disease but not ulcerative
colitis.3 However, no other aspects of childhood hygiene
were associated
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- Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: a case control study
- A E Duggan, I Usmani, K R Neal, and R F A Logan
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