SCIENCE ALERT
The medium is the messenger
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Comment
Enteropathogenic Escherichia coli (EPEC) is an
important category of diarrhoeagenic bacteria causing acute and chronic
diarrhoea in young children in both developing and developed countries, and sporadic cases in adults.1 There has been rapid recent progress in understanding the early stages of EPEC pathogenesis and the
events involved in the formation of the characteristic attaching-effacing (A/E) lesion,2 3
where EPEC attach to the mucosal surface and transform finger-like microvilli into a
pedestal-like structure with which the bacterium makes intimate contact.4 5
The main reasons for this progress are the
availability of in vitro cell culture models which reproduce the
lesion,6 the ability to recognise easily the lesion by
fluorescence and electron microscopy,7 and the existence
of the "virtual" EPEC laboratory spanning several continents, where
researchers from different institutes have shown a ready willingness to
exchange ideas, bacterial strains and expertise. Just such a
co-operative paper has been published by Knutton and
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This article has been cited by other articles:
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WINSTANLEY, C., HART, C. A.
(2001). Type III secretion systems and pathogenicity islands. J Med Microbiol
50: 116-126
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