GUT 1998;43:592-594 ( November )

LEADING ARTICLE

Helicobacter pylori induced apoptosis

The first 150 words of the full text of this article appear below.

	Introduction

Apoptosis, like Helicobacter pylori, has a long history, extending back into the 19th Century.¹ Apoptosis was ignored or forgotten, just like H pylori, only to reemerge relatively recently. However, with the current exponential increase in the number of publications concerning H pylori, and in those written about apoptosis, it was only a matter of time before the influence of H pylori on apoptosis was investigated. We shall review the recent evidence that indicates that H pylori is capable of inducing apoptosis in gastric epithelial cells, and explore the mechanisms and major implication of this findingthat an alteration of gastric epithelial apoptosis may relate to the outcome of chronic H pylori colonisation.

	Apoptosis in the stomach

The morphological changes occurring in a cell undergoing non-necrotic cell death were termed apoptosis by Kerr and coworkers in 1972.² Although apoptosis is often used interchangeably today with the term "programmed cell death", implying gene transcription . . . [Full text of this article]

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