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Measles virus and Crohn's disease: view of a medical virologist
| The first 150 words of the full text of this article appear below. |
Some recent reports have claimed that persistent measles virus
infection is involved in the aetiology or pathogenesis, or both, of
Crohn's disease. Using a variety of techniques, such as direct
electron microscopy, immunohistochemistry and in situ hybridisation,
these authors report that measles virus particles, protein or RNA were
detected in tissues from patients with Crohn's disease.1-5 These observations led to the hypothesis that
exposure to measles virus early in life, either during pregnancy, or as a consequence of postnatal infection by wild type measles virus or
measles vaccination, predisposes to inflammatory bowel disease (IBD).6 7
These claims prompted publication of several
critical commentaries and responses and led to a case control study
which did not support an association between measles virus vaccination and IBD.8-19 The comments focused on
the possible short-comings of the methods used by the researchers as
well as the choice of control cohorts with respect to their exposure
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This article has been cited by other articles:
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Iizuka, M, Saito, H, Yukawa, M, Itou, H, Shirasaka, T, Chiba, M, Fukushima, T, Watanabe, S
(2001). No evidence of persistent mumps virus infection in inflammatory bowel disease. Gut
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[Abstract] [Full Text] -
Iizuka, M, Chiba, M, Yukawa, M, Nakagomi, T, Fukushima, T, Watanabe, S, Nakagomi, O
(2000). Immunohistochemical analysis of the distribution of measles related antigen in the intestinal mucosa in inflammatory bowel disease. Gut
46: 163-169
[Abstract] [Full Text]
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