GUT 1998;43:735-736 ( December )

LEADING ARTICLE

Interleukin 12 and Th1 responses in inflammatory bowel disease

The first 150 words of the full text of this article appear below.

Immune phenomena are believed to play a key role in the pathogenesis of tissue damage in Crohn's disease and ulcerative colitis.^{1 2} Although some of the immunological perturbations seem to be shared by Crohn's disease and ulcerative colitis, there are important distinguishing features, possibly reflecting different pathways of immune mediated intestinal inflammation. Evidence indicates that macrophage and T cell derived cytokines play a key role in the amplification and perpetuation of the inflammatory response in both disorders.³ No aberrant cytokine secretion has been documented in inflammatory bowel disease (IBD) and no convincing evidence has as yet been provided that cytokine changes occur as a result of disease specific immune activation. However, a number of quantitative changes in the secretion and/or activity of both proinflammatory and regulatory cytokines have been reported in Crohn's disease and ulcerative colitis. Based on variation in the magnitude of these changes there seem to be different cytokine . . . [Full text of this article]

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