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Depletion of the enteric nervous system by gene targeting results in haemorrhagic necrosis of the ileum
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Comment
Over the past few years it has become increasingly clear that new
insights into the physiology of the gut are being made by non-gastroenterologists, often working on "blue-sky" projects with
no clinical relevance. One such project, published in Cell earlier this year, illustrates this point well.
Astrocytes are cells with branching cytoplasmic processes which
surround nerves. Some of the processes are directed towards capillaries
and others towards neurones. They provide structural support for the
neurone, play a role in maintaining the blood-brain barrier, and are
also important in repair after injury. They contain a characteristic
protein-glial fibrillary acidic protein (GFAP). Bush and colleagues
used the GFAP promoter to target the thymidine kinase of herpes simplex
virus (HSV-TK) into astrocytes in transgenic mice. In proliferating
cells exposed to the antiviral agent ganciclovir (GCV), HSV-TK
metabolises GCV to produce toxic nucleotides which kill the cells
expressing the transgene. Untreated transgenic mice
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This article has been cited by other articles:
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Gelderman, K A, Zijlmans, H J M A A, Vonk, M J, Gorter, A
(2004). CD55 expression patterns on intestinal neuronal tissue are divergent from the brain. Gut
53: 507-513
[Abstract] [Full Text]
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