Different management for Helicobacter pylori positive and negative patients with gastro-oesophageal reflux disease?
J M Lee, C A O'Morain
Department of
Gastroenterology, Meath/Adelaide hospitals, Trinity
college, Dublin, Ireland
Correspondence to: Professor Colm A O'Morain, Department of Gastroenterology, Meath Hospital, Heytesbury Street, Dublin 8, Ireland.
| The first 150 words of the full text of this article appear below. |
 |
Summary |
|---|
Available evidence would suggest that Helicobacter
pylori infection does not contribute to the pathogenesis of
gastro-oesophageal reflux disease. The prevalence of H
pylori infection in patients with reflux disease is no greater
than that in control populations. There are some data suggesting that
the organism has a protective role: patients with duodenal ulcers
develop reflux disease after H pylori eradication, whereas
in patients with oesophageal reflux those with H pylori
infection have less severe reflux changes. There is also evidence
indicating that the presence of H pylori augments the
anti-secretory properties of both the H2 receptor antagonists and proton pump inhibitors (PPIs), suggesting that eradication therapy may not be beneficial. However, the considerable recent interest in the association between H pylori and
reflux disease has largely been generated by studies outlining the
interactions between H pylori infection and acid
suppression in the long term. In H pylori positive
patients, therapy
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Gastro-oesophageal reflux
-
Pancreatic cancer
-
Stomach and duodenum
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Campylobacter, Salmonella, Shigella, Escherichia coli
-
Helicobacter pylori
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