Importance of changes in epithelial cell turnover during Helicobacter pylori infection in gastric carcinogenesis
M Antia, A Armuzzia, A Gasbarrinib, G Gasbarrinia
a Cattedra di Medicina Interna II, Università
Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy, b Istituto di Patologia Medica, Università Cattolica
del Sacro Cuore, Rome, Italy
Correspondence to: Dr Anti.
| The first 150 words of the full text of this article appear below. |
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Summary |
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The role of Helicobacter pylori in gastric
carcinogenesis is supported almost exclusively by epidemiological data
and prospective histopathological studies. From biological and
molecular points of view, there is no evidence that H
pylori or its cytotoxic products have any mutagenic effects.
Nevertheless, this infection is associated with profound changes in the
pattern of epithelial cell turnover in gastric glands, though the
importance of these changes in gastric carcinogenesis is still
controversial. H pylori infection increases cell
proliferation and alters the distribution of cycling cells within these
glands, but these changes can be reversed by successful eradication of
the infection. Apoptosis seems to be increased in gastric epithelial
cells during H pylori infection, as shown by in vitro
studies. There is some, though no conclusive, evidence that this
finding also occurs in H pylori positive subjects. It seems that cagA status influences the effect of H
pylori on epithelial apoptosis in
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