Helicobacter pylori: the gastric cancer problem
D Forman
Centre for Cancer Research,
University of Leeds, Arthington House, Cookridge Hospital, Leeds
LS16 6QB, UK
| The first 150 words of the full text of this article appear below. |
Gastric cancer is the second most common fatal malignancy in the world and is the cause of more than 750 000 deaths annually.1 In 1990, it was the fourteenth most frequent cause of death globally and, despite a general decline in the incidence, projections indicate that the annual number of new cases will increase significantly in the developing world during the next few decades as a result of adult population growth.1 Most gastric cancer is diagnosed at an advanced stage and survival is uniformly poor, usually no more than 15% at five years.2
There is now considerable evidence in support of an aetiological
association between Helicobacter pylori infection and
gastric cancer.3 Infection causes gastritis and the
natural history of H pylori associated gastritis over a
period of decades is one of increasing degenerative changes and
evolution towards atrophy, metaplasia and dysplasia.4 One
prospective study has established that there is a significantly
increased
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Pancreatic cancer
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Stomach and duodenum
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Campylobacter, Salmonella, Shigella, Escherichia coli
- Helicobacter pylori
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