Acid suppression and gastric atrophy: sifting fact from fiction
R M Genta
Departments of Pathology,
Medicine, and Microbiology and Immunology, Pathology 113, Veterans Affairs Medical Center and Baylor College of
Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA
| The first 150 words of the full text of this article appear below. |
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Summary |
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Prolonged pharmacological acid suppression is associated with various histological changes in the gastric mucosa, particularly in Helicobacter pylori infected patients. In a number of subjects these changes include a shift in the gastric inflammation from the antrum to the corpus. This finding has been interpreted as gastric atrophy, and the possibility that acid suppression accelerates the progress of lesions that may lead to gastric cancer has been considered. Two recent studies on the relation between treatment with proton pump inhibitors and atrophic gastritis have yielded apparently contradictory results. These studies are reviewed in detail here and some of the possible reasons for the discrepant conclusions are explored. In particular, the way the terms "gastric atrophy" and "atrophic gastritis" are used is examined critically.
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What is gastric atrophy? |
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As seen in histological preparations, the mucosa of the normal
gastric corpus consists of a layer of mucous cells invaginating into
shallow pits, which merge with the
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