Blood tests in the management of Helicobacter pylori infection
D Vairaa, J Holtonb, M Menegattia, F Landia, C Riccia, A Ali'a, L Gattaa, S Farinellia, C Acciardia, B Massardia, M Migliolia, the Italian Helicobacter pylori Study Group
a Department of Internal Medicine,
University of Bologna, Via Massarenti 9, 40138 Bologna, Italy, b Department of Bacteriology,
University College of London Medical School, London, UK
Correspondence to: Dr Vaira.
| The first 150 words of the full text of this article appear below. |
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Summary |
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There are three main types of blood test available for the
management of Helicobacter pylori infection: those that
detect an antibody response; tests of the pathophysiological state of the stomach; and those that indicate an active infection. Enzyme linked
immunosorbent assay (ELISA) based kits are the most numerous of the
commercially available tests. Originally the kits used crude antigen
preparations but many of the newer kits use a more purified antigen
preparation giving increased specificity but a lower sensitivity. The
sensitivity, specificity, and predictive values of the tests can also
be affected by the population under test and coexistent disease in the
patients. Near patient test kits are based on either latex
agglutination or immunochromatography. Generally, they have low
sensitivities compared with laboratory tests. Commerical western
blotting kits have also been developed and are used to detect the
presence of specific virulence markers. The exact role of serology in
the
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