Helicobacter pylori: the size of the problem
J Parsonnet
HRP Building, Room T225,
Stanford University, Stanford, CA 94305-5405, USA
| The first 150 words of the full text of this article appear below. |
| |
Introduction |
|---|
My task is to describe the magnitude of the problem
Helicobacter pylori poses worldwide. This is a daunting
assignment for, while it would be relatively simple to summarise the
prevalence of H pylori, to characterise those at risk for
infection, and to delineate incidence trends, it is far more difficult
to quantify the actual disease that H pylori causes.
Certainly, H pylori is an extraordinarily common
infection. Its mere commonness, however, is not in itself a problem.
Rather, it is the propensity H pylori has for causing
illness that determines its public health significance. Unfortunately,
for several reasons, the total extent of disease worldwide is far more
difficult to quantify than the amount of infection. Firstly, H
pylori related diseases (for example, ulcer disease) are often
treated empirically without resorting to diagnostic testing. There are,
therefore, very incomplete data on the incidence and corresponding
morbidity for these processes. Secondly, because
This article has been cited by other articles:
-
Chui, S. Y., Clay, T. M., Lyerly, H. K., Morse, M. A.
(2005). The Development of Therapeutic and Preventive Vaccines for Gastric Cancer and Helicobacter pylori. Cancer Epidemiol. Biomarkers Prev.
14: 1883-1889
[Abstract] [Full Text] -
Zucca, E., Bertoni, F.
(2005). Another Piece of the MALT Lymphomas Jigsaw. JCO
23: 4832-4834
[Full Text] -
Perez-Perez, G. I., Sack, R. B., Reid, R., Santosham, M., Croll, J., Blaser, M. J.
(2003). Transient and Persistent Helicobacter pylori Colonization in Native American Children. J. Clin. Microbiol.
41: 2401-2407
[Abstract] [Full Text] -
Kwon, D. H., Lee, M., Kim, J. J., Kim, J. G., El-Zaatari, F. A. K., Osato, M. S., Graham, D. Y.
(2001). Furazolidone- and Nitrofurantoin-Resistant Helicobacter pylori: Prevalence and Role of Genes Involved in Metronidazole Resistance. Antimicrob. Agents Chemother.
45: 306-308
[Abstract] [Full Text] -
Kwon, D. H., Kim, J. J., Lee, M., Yamaoka, Y., Kato, M., Osato, M. S., El-Zaatari, F. A. K., Graham, D. Y.
(2000). Isolation and Characterization of Tetracycline-Resistant Clinical Isolates of Helicobacter pylori. Antimicrob. Agents Chemother.
44: 3203-3205
[Abstract] [Full Text] -
Kwon, D.-H., El-Zaatari, F. A. K., Kato, M., Osato, M. S., Reddy, R., Yamaoka, Y., Graham, D. Y.
(2000). Analysis of rdxA and Involvement of Additional Genes Encoding NAD(P)H Flavin Oxidoreductase (FrxA) and Ferredoxin-Like Protein (FdxB) in Metronidazole Resistance of Helicobacter pylori. Antimicrob. Agents Chemother.
44: 2133-2142
[Abstract] [Full Text] -
Keates, S., Keates, A. C., Warny, M., Peek, R. M. Jr., Murray, P. G., Kelly, C. P.
(1999). Differential Activation of Mitogen-Activated Protein Kinases in AGS Gastric Epithelial Cells by cag+ and cag- Helicobacter pylori. J. Immunol.
163: 5552-5559
[Abstract] [Full Text] -
Jiang, B., Jordana, M., Xing, Z., Smaill, F., Snider, D. P., Borojevic, R., Steele-Norwood, D., Hunt, R. H., Croitoru, K.
(1999). Replication-Defective Adenovirus Infection Reduces Helicobacter felis Colonization in the Mouse in a Gamma Interferon- and Interleukin-12-Dependent Manner. Infect. Immun.
67: 4539-4544
[Abstract] [Full Text]
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
