The European meeting on Helicobacter pylori: therapeutic news from Lisbon
U Peitza, M Menegattib, D Vairab, P Malfertheinerb
a Department of Gastroenterology, Hepatology and
Infectiology, Otto-von Guericke-University Magdeburg, b Department of Internal Medicine, University of Bologna, Via
Massarenti 9, 409138 Bologna, Italy
Correspondence to: Dr U Peitz, Department of Gastroenterology, Hepatology and Infectiology, Otto-von Guericke-University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
| The first 150 words of the full text of this article appear below. |
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Summary |
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The current standard of Helicobacter pylori treatment
has been confirmed by the studies presented at the Lisbon
workshop
that is, one of three one week proton pump inhibitor (PPI)
based triple therapies comprising a twice daily standard dose of a PPI
in combination with two of the following antimicrobial agents:
clarithromycin, amoxycillin, or a nitromidazole. This standard of
treatment is also highly efficacious and cost-effective in routine
community practice. The current data confirm the equivalence of
ranitidine bismuth citrate to PPI, and of azithromycin to
clarithromycin. The optimum dose for azithromycin has not yet been
defined. There is some evidence that in certain regions treatment for
more than one week may be advantageous. The reasons are still not
clear. However, microbial resistance may be one important factor, as it
has a substantial effect on treatment outcome and the prevalence of
resistance varies considerably in different areas. The negative impact
of
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